Nationwide Children's Hospital

Research Associate- Research Microbial Pathogen Staff

  • Nationwide Children's Hospital
  • Columbus, OH 43205
  • 15 days ago

Advertisement

Job Description

Overview:

Research Associate - Research Microbial Pathogen Staff

Our team is part of the Center for Microbial Pathogenesis (CMP) at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, which exists to answer questions that will improve the early diagnosis, treatment and outcomes of society’s most important pediatric diseases by combining high-quality, fact-based lab discoveries and innovative patient-based research.

Our passion and vision are to rapidly translate research discoveries into effective treatments and prevention strategies for pediatric and adult patients afflicted with chronic and recurrent infectious disease.

The Bakaletz Lab utilizes multidisciplinary and innovative approaches to advance our understanding as to how bacterial biofilms contribute to pathogenesis, chronicity and recurrence of disease.

To date, our focus has primarily been on polymicrobial diseases of the human respiratory tract, however we are rapidly expanding our areas of interest to diseases problematic at other anatomical sites via collaboration with multiple colleagues.

Dr. Bakaletz’ team’s focus is on using acquired advanced understanding to design and test novel therapeutic approaches as well as prevention strategies in vitro, the ultimately in vivo via use of several well-established models of human disease.

Specifically, the Bakaletz laboratory is interested in the interface between the bacterial biofilm and the host’s innate immune system to better empower the host to be able to eradicate biofilms or prevent them from forming.

Advances in the laboratory are rapidly translated via interaction with pharmaceutical companies and/or via recently founded start-up companies.

The long-term goal of our research program is to gain an increased understanding of the role of recalcitrant bacterial biofilms in the pathogenesis of chronic and recurrent diseases the use this understanding to design and test novel therapeutic approaches and vaccine development.

Ultimately, the passion and vision of the Bakaletz laboratory is to rapidly translate research discoveries into lasting treatment options for pediatric and adult patients afflicted with bacterial diseases wherein biofilms present significant challenges to treatment or resolution.

To achieve these goals, we actively engage in translating our findings from the bench to the clinic whenever possible.

Why Nationwide Children's Hospital?

:

The moment you walk through our doors, you feel it.

When you meet our patient families, you believe it.

And when you talk with anyone who works here, you want to be part of it.

Welcome to Nationwide Children’s Hospital,

Where Passion Meets Purpose.

Here,

Diversity, Equity and Inclusion are integrated into our core values and practices.

We are passionate about building, sustaining and evolving an inclusive and equitable environment.

We are seeking individuals who live these values and want to share their experiences and efforts in support of our collective mission.

We’re 14,000 strong.

And it takes every one of us to improve the lives of the kids we care for, and the kids around the world we’ll never meet.

Kids who live healthier, fuller lives because of the knowledge we share.

We know it takes

a

Collaborative Culture to deliver on our promise to provide the very best, innovative care and to foster new discoveries, made possible by the most groundbreaking research.

Anywhere.

Ask anyone with a Nationwide Children’s badge what they do for a living.

They’ll tell you it’s

More Than a Job.

It’s a calling.

It’s a chance to use and grow your talent to make an impact that truly matters.

Because here, we exist simply to help children everywhere.

Nationwide Children’s Hospital.

A Place to Be Proud.

Responsibilities:

Responsibilities

Develops and implements research projects in conjunction with PI; identifies methodological problems in research protocols and develops solutions to those problems.

Independently performs assessments of immune responses to immunization and/or viral/bacterial infection; assays specificity and avidity of monoclonal and humanized antibodies for targeted & related antigens; assists with and/or independently conduct pre-clinical studies in preparation for entry into clinical studies.

Collects and analyzes data in accordance with appropriate statistical procedures and prepare reports, inclusive of graphs, tables, and captured images of the results of studies.

Maintains detailed laboratory notebooks and electronic records.

Monitors use of reagents and supplies to assure budgetary constraints are followed.

Maintains a clean working area and adheres to proper safety techniques and procedures.

Communicates daily with PI and lab teammates to discuss results, progress, and coordinate efforts.

To be successful in this position, the ideal candidate will:

Independently execute research studies according to grant and research proposals within stated deadlines.

Analyze data and prepare results of experimental findings for presentation to colleagues, at professional conferences and for publication in scientific journals.

Assure compliance with research protocols and safety requirements.

Oversee and direct undergraduate students, research interns and other trainees in the timely completion of experiments, proper conduct of research and accurate record keeping.

Support a collaborative research environment and provides guidance on technical and operational aspects of research.

Actively participate in collaborative lab meetings to present data.

Read and review scientific literature.

Manage laboratory needs (e.g. ordering, organizing, training and compliance).

Qualifications:

Qualifications Education:

MS in Biomedical Sciences with two years of laboratory research experience or a BS with 5 years of laboratory research experience Specific skills:

Skilled in laboratory techniques required for microbiological and immunological assessments (e.g. sterile technique, ELISA, Western blotting, FACS, immunofluorescent microscopy, SPR), protein purification, cell culture (including hybridoma culture and antibody purification).

Experience with animal models is required.

Must have strong attention to detail and high degree of accuracy in work.

Must have excellent verbal and written communication and organizational skills.

Must be able to work independently and as part of a collaborative team.

Willing and eager to learn novel and evolving technologies.

Excellent math skills are required.

Utilizes software applications to assemble, format and perform statistical analyses of data.

Experience with scanning confocal laser microscopy is preferred, but not required.

Minimum Physical Requirements:

70% Conducting research studies

20% Collecting and analyzing data

10% Preparing reports and miscellaneous paperwork associated with research

10% Kneeling / reaching

100% Finger dexterity

100% Talking / hearing / seeing

5% Lifting / carrying weight 0-20 pounds for 1-5 minutes

The above list of duties is intended to describe the general nature and level of work performed by individuals assigned to this classification.

EOE M/F/Disability/Vet

Similar Jobs